Harnessing NGS-based MRD detection: Insights from a retrospective AML cohort study

Acute Myeloid Leukemia (AML) is the most common acute leukemia in adults affecting 2-6 adults per 100,000k globally.​ 

With relapse rates as high as 50%, routine measurable residual disease (MRD) monitoring is key. Detecting even a few residual leukemic cells can provide a more comprehensive picture of the current AML status of a sample.

The SureSeq™ Myeloid MRD Plus NGS Panel incorporates a key range of AML-associated biomarkers, allowing for the rapid generation of extensive genomic profiles from bone marrow and peripheral blood.

Hear from Dr. Sean Glenn, Roswell Park Cancer Institute, as he shares his insights using the SureSeq Myeloid MRD Plus Panel* in a retrospective cohort study of research specimens collected from patients undergoing AML treatment.​

Learn about the ability of the SureSeq Myeloid MRD Plus NGS Panel to assess residual disease signals as compared to other existing technologies and how targeted NGS-based panels can enhance our understanding of AML MRD.

Learning Objectives:

• Analyze the clinical significance of MRD monitoring: Evaluate the role of MRD as a prognostic indicator in AML and understand how detecting low-level residual leukemic cells can predict relapse risk and inform treatment strategies.
   
• Compare NGS-based MRD detection with traditional technologies: Contrast the capabilities of the SureSeq Myeloid MRD Plus NGS Panel against existing methods—such as flow cytometry and qPCR—specifically regarding its sensitivity to broad biomarker ranges and complex variants like FLT3-ITDs. 
   
• Evaluate genomic profiling in retrospective research: Assess the insights gained from a retrospective cohort study of research specimens collected from patients undergoing AML treatment to understand how high-sensitivity NGS panels can be integrated into research workflows to generate comprehensive genomic profiles from bone marrow and peripheral blood. 
   

*SureSeq™: For Research Use Only. Not for Use in Diagnostic Procedures