NAMs: Precision Automation Advancing Cardiac Organoid Development
New Approach Methodologies (NAMs) are revolutionizing disease modeling with human-based models that enhance predictive accuracy. iPSC-derived cardiac organoids lead this innovation, offering insights into heart development and disease. Challenges in scaling these organoids stem from complex differentiation and manual selection, necessitating robust automation.
Precision Automation in Heart Models
Advancements in precision automation, demonstrated by Hannover Medical School (MHH), streamline cardiac organoid development. These 3D models replicate human heart properties, providing insights into developmental processes and overcoming manual selection challenges.
Automated Organoid Development
This study introduces a workflow that precisely assesses and embeds cell aggregates, ensuring high-quality heart-like structures. Automation optimizes conditions for organoid formation, enhancing research reliability and scalability.
Benefits of Automation
Automation improves organoid research by:
Enhancing identification of high-quality organoids.
Increasing reproducibility and surpassing manual methods.
Reducing training time for staff.
Streamlining processes for efficiency and documentation. This approach achieves a 90% success rate, meeting criteria consistently.
Empowering Researchers
The case study presents a framework for integrating automation into organoid research, enabling time-saving, expert-level results, and increased throughput. As legislative and regulatory shifts favor NAMs, these advancements promise a transformative future in cardiac research, aligning practices with ethical standards.
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Sartorius is a leading international partner to the biopharmaceutical research and manufacturing industries. The Lab Products & Services Division focuses on innovative laboratory instruments and consumables for research and quality assurance laboratories in pharmaceutical and biopharmaceutical companies as well as academic research institutions. The Bioprocess Solutions Division supports customers with a broad product portfolio focused on single-use solutions for the safer, faster, and more sustainable production of biotech drugs, vaccines, and cell and gene therapies.
