At the Robert-Debré Hospital in Paris, part of AP-HP Nord and Université Paris Cité, the molecular genetics laboratory plays a key role in advancing rare disease research. To manage the growing diversity and volume of genetic samples, including constitutional, somatic, and prenatal cases, the lab implemented an automated next-generation sequencing (NGS) workflow powered by Agilent’s integrated solutions.
By adopting a single-vendor strategy, the team streamlined sample preparation, target enrichment, and quality control processes using automated systems such as the Magnis NGS Prep* and Bravo NGS* Workstations. This harmonized approach has increased throughput to more than 5,000 samples annually, while maintaining accuracy and reproducibility. The lab now processes 96 constitutional samples every 3–4 weeks and 48 somatic samples weekly, significantly improving operational efficiency.
This case study highlights how automation and standardization can accelerate rare disease research by optimizing laboratory workflows, reducing manual steps, and supporting scalability. Discover how a unified NGS approach is transforming genomic research at one of Europe’s leading hospitals.
*For Research Use Only. Not for use in diagnostic procedures.